Browsing by Subject "Atmospheric movements"
Now showing items 1-5 of 5
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Conference Object
Computational fluid dynamics (CFD) Simulations of aerosol deposition in the lungs
(TSFP-9, 2015)In the current study, Large Eddy Simulations (LES) are used to investigate the transport and deposition of inhaled aerosol particles (dp = 0.1, 0.5, 1, 2.5, 5, 10 μm) in a realistic geometry of the human airways under ...
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Article
Direct numerical simulation of particle laden flow in a human airway bifurcation model
(2016)During the delivery of inhaled medicines, and depending on the size distribution of the particles in the formulation, airway bifurcations are areas of preferential deposition. Previous studies of laminar flow through airway ...
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Conference Object
The effect of flow rate, head position, and inhaler orientation on the airflow and particle deposition in an mri-based mouth-throat geometry
(International Symposium on Turbulence and Shear Flow Phenomena, TSFP10, 2017)The mouth-throat plays a key role in the administration of inhaled medicines. It is an area of intense filtration, where an unacceptably high fraction of the released drug dose is deposited and thus wasted. Due to the ...
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Article
In silico assessment of mouth-throat effects on regional deposition in the upper tracheobronchial airways
(2018)Regional deposition of inhaled medicines is a valuable metric of effectiveness in drug delivery applications to the lung. In silico methods are now emerging as a valuable tool for the detailed description of localized ...
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Article
Targeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Method
(2018)The pulmonary route presents an attractive delivery pathway for topical treatment of lung diseases. While significant progress has been achieved in understanding the physical underpinnings of aerosol deposition in the ...